4 edition of Human interferon, production and clinical use found in the catalog.
|Statement||edited by Warren R. Stinebring and Paul J. Chapple.|
|Series||Advances in experimental medicine and biology ;, v. 110|
|Contributions||Stinebring, Warren R., Chapple, Paul J.|
|LC Classifications||QR187.5 .I572 1977|
|The Physical Object|
|Pagination||viii, 221 p. :|
|Number of Pages||221|
|LC Control Number||78013393|
Specific molecular sites or structures on or in cells with which interferons react or to which they bind in order to modify the function of the | Explore the latest full-text research PDFs. If the address matches an existing account you will receive an email with instructions to reset your password.
Interferon synthesis is stimulated by a variety of factors including exposure to virus, antigen, or antibody and various mitogens. Three classes of interferon have been described and multiple subtypes identified. The use of interferon in clinical trials for the treatment of cancer and viral infections has been limited by the relatively low quantities of interferon available. Interferon beta-1b is a protein in the interferon family used to treat the relapsing-remitting form of multiple sclerosis (MS). Interferon beta-1b is a natural human protein (molecular weight ~18, Da) that is produced in the body in response to viral infection and has antiviral activity. It has been shown to slow the advance of MS and reduce the frequency of attacks. It is believed that.
The study made use of a natural interferon (Alfaferone), cultured from human cell lines, rather than a recombinant interferon such as those previously described. The study involved 22 FIV+ cats, an inexplicably small control group of 5 FIV+ cats given placebo, and 3 FIV+/FeLV+ cats distributed among the two other groups. Mihaljevic S Y () First clinical experiences with omega-interferon in the treatment of chronic gingivitis-stomatitis-oropharyngitis of cats. Praktische Tiera Riondato F et al () Effects of interferon alpha therapy on peripheral blood lymphocyte subsets from FIV .
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Human Interferon: Production And Clinical Use (Advances In Experimental Medicine And Biology): Medicine & Health Science Books @ Human Interferon Production and Clinical Use. Editors (view affiliations) Warren R. Stinebring; Downloads; Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume ) Download book PDF.
Chapters Table of contents (17 chapters) Production of Interferon in Human Cell Cultures by a New, Potent Viral Inducer. Get this from a library. Human interferon, production and clinical use. [Warren R Stinebring; Paul J Chapple;] -- This volume stems from a workshop held at the W.
Alton Jones Cell Science Center, Lake Placid, New York, MayThe Center is an operational unit. Human Interferon Production and Clinical Use.
Editors: Stinebring, W. (Ed.) Free Preview. Buy this book eB68 € price for Spain (gross) Buy eBook ISBN ; Digitally watermarked, DRM-free; Included format: PDF; ebooks can be used on all reading devices.
ISBN: OCLC Number: Language Note: English. Description: 1 online resource: Contents: Large Scale Production and Properties of Human Leukocyte Interferon Used in Clinical Trials --New Microcarriers for the Large Scale Production of Anchorage-Dependent Mammalian Cells --Effect of Low Levels of Cyclic.
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Warren R. Stinebring, Paul J. Chapple. Plenum Press, - Science - pages. 0 Reviews. From inside the book. What people are saying. PDF Human Interferon: Production and Clinical Use Read Online. Report. Browse more videos. Playing next. Collection Book A Clinical Guide to the Treatment of the Human Stress Response (Springer Series on.
SheliaDurham. New Book Principles of Human Joint Replacement: Design and Clinical Application. The book is organized into four parts. Human interferon Part I presents papers on recombinant DNA production of interferon.
It includes studies on the synthesis of human immune interferon in E. coli and monkey cells; the expression of human β interferon gene in heterologous cells; and the molecular activities of recombinant and hybrid leukocyte interferons. Early clinical studies.
The discovery of interferons was a result of research by Isaacs & Lindenmann in the field of viral interference , the ability of an active or inactivated virus to interfere with the growth of an unrelatedviral interference had been considered to be due directly to the action of one virus on the pathologic activity of a second agent.
Mark G. Papich DVM, MS, DACVCP, in Saunders Handbook of Veterinary Drugs (Fourth Edition), Pharmacology and mechanism of action. Recombinant omega interferon contained in Virbagen omega is produced by silkworms previously inoculated with interferon-recombinant baculovirus. It allows the production of pure interferon.
Omega interferon of feline origin, produced by genetic engineering, is. Part II deals with the biology of interferons, covering topics such as interferon production control process; the effect of interferon on cellular enzymes; and human amniotic interferon.
Part III examines the factors relevant to clinical application of interferons, including structure-function studies with human interferon-gamma and on human.
Human Interferon Genes (HIG) Production was estimated to be about 1, tomolecules of IFN-b per cell. The Swedish firm, Biogene, produced IFN-a and IFN-b through recombinant DNA techniques which are now under clinical trials.
It was found that genes responsible for the production of IFN- a and IFN-b had and nucleotides. Effective antiviral agents are needed to treat severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infection. We assessed the antiviral potential of recombinant interferons against two clinical isolates of SARS-CoV—FFM-1, from Frankfurt patients, and Hong Kong—replicated in Vero and Caco2 cells.
Interferon β was five to ten times more effective in Caco2 cells. Interferon, any of several related proteins that are produced by the body’s cells as a defensive response to viruses.
They are important modulators of the immune response. Interferon was named for its ability to interfere with viral proliferation. The various forms of interferon are the body’s most.
• Interferons are broken down into recombinant versions of a specific interferon subtype and purified blends of natural human interferon. • Many of these are in clinical use and are given intramuscularly or subcutaneously • Recombinant forms of alpha interferon include: • Alpha-2a drug name Roferon • Alpha-n3 drug name AlferonN.
Today, the basic mood of researchers and clinical investigators, both at the center and on the periphery of interferon studies, Production and Characterization of Human Leukocyte Interferon. Hill. Pages Lymphoblastoid Interferon: Production and Characterization. Abstract. This book provides the discussion of products of biotechnology of recombinant DNA.
The contents include: Recombinant DNA techniques; isolation, cloning, and expression of genes; from somatostatin to human insulin; yeast; an alternative organism for foreign protein production; background in human interferon; preclinical assessment of biological properties of recombinant DNA derived.
Abstract. Interferon (IFN)-gamma was produced with a high yield in cultures of human peripheral mononuclear cells by combined stimulation with OK and staphylococcal enterotoxin B. Human mononuclear cells cultured in serum-free medium produced several times as much IFN as those in RPMI medium containing 10% fetal bovine serum.
The book demonstrates how research on interferon led to new clinical definitions of cancer and a new rationale for therapeutic use of the drug. Interferon provides a marvellous insight into the development of one of the most controversial drugs of our time.
It enhances our understanding of how medicine manufacture and marketing all played a Format: Paperback. But the whole clinical development of interferon was put on hold then for some years, partly because of our inability to make enough interferon – a problem not solved until the development of large scale production in human cells by Kari Cantell in Helsinki, using human leukocytes, and by Norman Finter in the UK, using human lymphoblastoid.
Clinical trials are research studies that involve people. The clinical trials on this list are studying Recombinant Interferon. All trials on the list are supported by NCI. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out.
Clinical trials look at new ways to prevent, detect, or treat disease.Explore the latest full-text research PDFs, articles, conference papers, preprints and more on INTERFERON. Find methods information, sources, references or conduct a literature review on INTERFERON.
Stein, B. L. & Tiu, R. V. Biological rationale and clinical use of interferon in the classical BCR-ABL-negative myeloproliferative neoplasms. J. Interferon Cytokine Res. 33, – ().